Alabama’s Girls Engaged in Math and Science University, GEMS-U, project-based learning concept was created to deeply engage girls in Science, Engineering, and Mathematics through 21st Century Technology tools and pedagogies. The Alabama Learning Exchange, ALEX, a 2009 winner of the Center for Digital Education’s “Best of the Web,” in collaboration with state and national partners, including Apple iTunes U, is creating a robust learning community full of podcasts and exciting learning resources designed to motivate girls to envision themselves as powerful contributors to 21st Century thought and paradigms. The project will culminate in girls building projects using technology to research and express STEM key concepts. Maryland will highlight projects that combine funding to maximize effective technology integration in their Math-Science Partnership Grants. The Maryland model for STEM builds upon a priority to refine the math, science, and technology curricula, allowing for a trans disciplinary approach that incorporates the latest technology. This includes the Virtual Learning Environments (VLE) at Chesapeake High School in Baltimore County and cost-effective technology solutions for teacher professional development.